New method to reactivate genes that "suppress" tumors

A study published by University College London on the 27th said that some genes that have a "suppressive" effect on tumors are often "closed" by cancer cells, and newly discovered methods can reactivate them to fight tumors.

 

According to reports, some genes can prevent the growth of tumors under active conditions, but cancer cells often use a protein called PRC2 to inhibit the function of these genes and "close" them.

 

Researchers at universities such as University College London, in a paper published in the journal Nature, Structures and Molecular Biology, found that if they "bound" the protein PRC2 with ribonucleic acid, it would not be able to "close" the gene.

 

In the experiment, the researchers first cultivated cells of some tumor tissues, in which the role of the above genes has been inhibited by the protein PRC2, but after using technology to bind the ribonucleic acid to the protein, the protein leaves the correlation. Genes, the ability of these genes to inhibit cancer cells are reactivated.

 

Professor Richard Jenner of University College London said that the next step is to test which types of cancer this method can be used for, and hope to develop new cancer therapies on this basis.

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